中文名稱:異綠原酸b
中文同義詞:ISOCHLOROGENICACIDB異綠原酸B;異綠原酸B;異綠原酸B(3,4-二咖啡酰奎寧酸);二咖啡??鼘幩?ISOCHLOROGENICACIDB異綠原酸B標(biāo)準(zhǔn)品;異綠原酸B(3;3,4-二咖啡酰奎寧酸;3,4-二咖啡??鼘幩?異綠原酸B)
英文名稱:IsochlorogenicAcidB
英文同義詞:IsochlorogenicacidB,froMLonicerajaponica;3,4-Dicaffeoylquinicacid;IsochlorogenicacidB;IsochlorogenicacidB,3,4-Dicaffeoylquinicacid;(1S)-1α,5α-Dihydroxy-3β,4α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β-cyclohexanecarboxylicacid;(1S)-4β,5α-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β,3β-dihydroxycyclohexanecarboxylicacid;1β,3β-Dihydroxy-4β,5α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1α-cyclohexanecarboxylicacid;ISOCHLOROGENICACIDB(RG)
CAS號:14534-61-3
分子式:C25H24O12
分子量:516.45

EINECS號:
異綠原酸b性質(zhì)
沸點(diǎn)810.8±65.0°C(Predicted)
密度1?+-.0.1g/cm3(Predicted)
儲(chǔ)存條件Sealedindry,Storeinfreezer,under-20°C
酸度系數(shù)(pKa)3.70±0.50(Predicted)
生物活性
3,4-Dicaffeoylquinic acid 是天然分離的,具有抗氧化,DNA 保護(hù),神經(jīng)保護(hù)和肝保護(hù)特性。3,4-Dicaffeoylquinic acid 具有凋亡介導(dǎo)的細(xì)胞毒性和 α-葡萄糖苷酶 (α-glucosidase) 抑制作用。3,4-Dicaffeoylquinic acid 具有獨(dú)特的抗病毒作用機(jī)制,即通過增加 TRAIL 來提高病毒清除率。
靶點(diǎn)
Human Endogenous Metabolite
體外研究 3,4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract, by having higher ferric reducing activity (EC 50 2.18 μg/ml), β-carotene bleaching activity (EC 50 23.85 μg/ml) and DPPH scavenging activity (EC 50 68.91 μg/ml). 3,4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23 (human lung adenocarcinoma) cell lines (EC 50 3.26 μg/ml) and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3,4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC 50 241.80 μg/ml.
化學(xué)性質(zhì)
類色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于金銀花,忍冬,杜仲。