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中文名稱:羥吡酮

中文同義詞:去屑劑;吡羅克酮乙醇銨;1-羥基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺復合鹽;吡羅克酮乙醇胺鹽;吡啶酮乙醇胺鹽(去屑劑OCTO);吡啶酮乙醇胺鹽;羥吡酮;羅酮奧拉明

英文名稱:Piroctoneolamine

英文同義詞:2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxylpyrazoleketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridonmonoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-onecompoundwith2-aminoethanol(1:1)

CAS號:68890-66-4

分子式:C16H30N2O3

分子量:298.43

EINECS號:272-574-2

羥吡酮 性質(zhì)

熔點 134.0 to 138.0 °C

儲存條件 2-8°C

形態(tài)neat

Merck 14,7502

InChIKeyBTSZTGGZJQFALU-UHFFFAOYSA-N

生物活性

Piroctone olamine 是一種吡啶衍生物。具有殺真菌作用。

靶點 

Antifungal

體外研究 

Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).

體內(nèi)研究 

This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).

WGK Germany 2

RTECS號UU7786150

海關編碼 2933399090

羥吡酮是一種高效、無毒無刺激的去屑劑，可以廣泛使用于去屑香波、養(yǎng)發(fā)液和護發(fā)素等洗護類化妝品中。